Elevated levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are non-specific markers of inflammation in the body and can be caused by a wide range of diseases and conditions. Some of the diseases and conditions that can cause high ESR and CRP include:
- Infections such as bacterial infections, viral infections, fungal infections, and parasitic infections.
- Autoimmune diseases such as rheumatoid arthritis, lupus, and inflammatory bowel disease.
- Malignancies such as lymphoma and multiple myeloma.
- Tissue injury or necrosis caused by trauma, surgery, or myocardial infarction.
- Chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD), chronic kidney disease, and inflammatory bowel disease.
- Vasculitis and other systemic diseases such as polymyalgia rheumatica and giant cell arteritis.
It is important to note that the presence of high ESR and CRP alone is not enough to make a definitive diagnosis, and further testing and evaluation are often needed to identify the underlying cause.