Why ESR is high in autoimmune disease?


ESR stands for erythrocyte sedimentation rate, which is a measure of how quickly red blood cells settle at the bottom of a tube over a specific period of time. It is a non-specific marker of inflammation, meaning that it can indicate the presence of inflammation in the body, but it does not indicate the cause or location of the inflammation.

In autoimmune diseases, the immune system attacks the body’s own tissues, leading to chronic inflammation. This inflammation can cause an increase in ESR, as the body produces more proteins, such as fibrinogen, that cause red blood cells to stick together and settle more quickly in the tube.

Additionally, in autoimmune diseases, there may be an increase in the number of white blood cells, such as lymphocytes and plasma cells, which can also contribute to a higher ESR.

Therefore, a high ESR level in combination with other clinical and laboratory findings may indicate the presence of an autoimmune disease. However, a high ESR level alone is not sufficient to make a diagnosis of an autoimmune disease, and further testing and evaluation by a healthcare professional are necessary.

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