Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs when the body’s immune system attacks the joints, leading to inflammation and damage. The exact cause of RA is not fully understood, but it is believed to be a combination of genetic and environmental factors.
Genetic factors play a significant role in the development of RA, as the disease tends to run in families. Several genes have been identified that are associated with an increased risk of developing RA, including the HLA-DRB1 gene.
Environmental factors such as smoking, infections, and hormonal changes have also been linked to the development of RA. In particular, smoking has been shown to increase the risk of RA and make the disease worse.
Ultimately, it is likely that a complex interplay between genetic and environmental factors contributes to the development of RA.
