Is CRP elevated in lupus?


C-reactive protein (CRP) is a protein produced by the liver in response to inflammation in the body. While CRP levels may be elevated in various conditions that cause inflammation, such as infections, autoimmune disorders, and cardiovascular diseases, it is not typically used as a diagnostic marker for lupus.

Lupus, also known as systemic lupus erythematosus (SLE), is an autoimmune disease that can affect multiple organs and tissues in the body, leading to a range of symptoms such as joint pain, skin rashes, fever, and fatigue. Diagnosis of lupus usually involves a combination of clinical symptoms, physical examination, and laboratory tests, such as antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) tests, complement levels, and other specific autoantibodies.

While CRP levels may be elevated in some lupus patients, especially during disease flares or in the presence of infections, it is not a specific or reliable marker for the diagnosis or monitoring of lupus. Other inflammatory markers, such as erythrocyte sedimentation rate (ESR) and serum cytokines, may also be elevated in lupus but are not specific to the disease.

Therefore, the diagnosis and management of lupus rely on a comprehensive evaluation of clinical, laboratory, and imaging findings, along with a careful assessment of individual patient factors and disease activity.

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